丁 燕,女,副教授,硕士研究生导师。 1980年6月出生。2003年6月毕业于吉林农业大学中药材学院中药学专业,获理学学士学位;2006年6月毕业于吉林农业大学中药材学院中药化学专业,获医学硕士学位;2010年2月毕业于韩国忠南大学大学药学院医药化学专业,获药学博士学位。2011年2月,韩国忠南大学医药品开发研究所,博士后出站。2009年,获国家教育部留学基金委“国家自费留学生奖”。2015年,获大连市“科技之星”。2017年,获得大连市科技进步二等奖。
1.主要学术研究方向:天然产物化学与功能性研究;食品质量控制与安全性研究
2.招收硕士生所在一级学科:食品科学与工程
3.目前承担主要课程: 本科生课程:食品化学、食品分析、仪器分析;
研究生课程:色谱分析、现代食品分析技术
4.指导硕士研究生情况:毕业11名,在读6名。
5.承担科研项目情况:主持并参与国家、省、市纵向和横向科研项目多项,目前承担的主要科研项目:
(1)辽宁省科技计划博士启动基金:基于MC3T3-E1、BMMs的细胞水平抗骨质疏松药效评价体系的构建及15种药食两用中药的活性评价(20121097),4万。
(2)辽宁省教育厅科技研究一般项目:韩茵陈中促进成骨细胞MC3T3-E1分化萜类物质的研究(L2012183),3万。
(3)教育部留学回国人员科研启动基金:基于MC3T3-E1的莲藕有效成分促进骨形成作用机理研究(教外司留[2013]693号),3万。
(4)大连市高层次人才项目:基于色谱分析分离平台的中药化学组分、成分库构建关键技术研究(2016RQ064),10万。
(5)辽宁省教育厅基本科研项目:基于工业色谱装备的天然产物化学分离制备平台的构建(2016J008),10万。
(6)辽宁省自然科学基金面上项目:基于HPLC-MS技术及化学计量学方法硫磺熏蒸对人参特征成分影响机制研究(2021-MS-299),5万。
(7)横向课题:3种药茶的质量指标筛选及测试分析研究(中国标准化研究院),20万。
6.发表论文情况:先后在Food Chemistry, Journal of Ethnopharmacology, Planta medica, Bioorganic & Medicinal Chemistry Letters, Biological & Pharmaceutical Bulletin, Bulletin of the Korean Chemical Society等刊物上发表论文40余篇。
主要代表作:
(1) Zhang Yanna, Wang Bin, Zhao Penghui, He Fan, Xiao Wei, Zhu Jingbo, Ding Yan*. A comprehensive evaluation protocol for sulfur fumigation of ginseng using UPLC-Q-TOF-MS/MS and multivariate statistical analysis. LWT: Food science and technology. 2021, 145, 111293 (SCI, 4.006)
(2) Wang Fengqi1, Zhang Yanna1, Wu Qi, Xiao Wei, Zhu Jingbo, Ding Yan*. Purity determination and uncertainty estimation of natural products sourcing chemical reference substances by high-performance liquid chromatography and differential scanning calorimetry. Microchemical journal. 2021, 166, 106257 (SCI, 3.594)
(3) Li Yan, Ding Yan*, Xiao Wei, Zhu Jing-Bo*. Investigation on the active ingredient and mechanism of Cannabis Sativa L. for treating epilepsy based on network pharmacology technology. Biotechnology & Biotechnological equipment. 2021, 35(1), 994-1009 (SCI, 1.227)
(4) Yajie Zhu, Yan Ding*,·Tian Dongxu, Li Yan, Zhuang Linwu, Wang Yinpeng, Xiao Wei, Zhu Jingbo *. Theoretical design and mechanism research of molecularly imprinted polymers for steviol glycosides. Journal of Molecular Modeling. 2021, 8 (on line) (SCI, 1.346)
(5) 吴金倩,朱靖博*,丁燕*,肖伟. 补骨脂中化合物系统性分离制备. 天然产物研究与开发. 2020, 32:38-46
(6) Zhu Jingbo,Cui Weibin,Xiao Wei,Ding Yan*,Huang Wenzhe,Tu Pengfei,Wang Yonghua. Isolation and enrichment of Ginkgo biloba extract by a continuous chromatography system. Journal of Separation Science. 2018, 41: 2432–2440. (SCI, 2.415)
(7) 朱靖博*,籍立新,肖 伟,丁 燕*,黄文哲,屠鹏飞,王永华. 反相二维色谱制备甘草中的黄酮类化合物. 中草药. 2018, 49(9), 2033-2040
(8) 朱靖博*,李文玉,肖 伟,丁 燕*,黄文哲,屠鹏飞,王永华. 反相二维液相色谱制备五味子中的木脂素. 色谱. 2018, 36(5), 464-473.
(9) 丁燕,王枫琦,张开梅,张立鹏,苍小鑫,杜香琳,朱靖博*,萧伟. 基于QSAR模型的食品谱效关系研究:以植物黄酮为例. 中国食品学报. 2018,18(8),239-246.(EI)
(10) 丁燕,张立鹏,王靖,张开梅,王枫琦,萧伟,朱靖博*. 基于微核试验及彗星试验评价丹酚酸A、丹酚酸B及原儿茶醛的抗突变活性. 中国食品学报. 2018,18(9),311-316.(EI)
(11) 苍小鑫,赵小明,钟润涛,王文霞,尹恒,朱靖博,丁燕*. 基于液滴微流控的壳寡糖植物免疫诱导剂荧光检测. 农业工程学报. 2017,33(2):302-307.(EI)
(12) 徐飞飞,丁燕*,张海东,郭盈莹,曲丹,寇自农,肖伟,朱靖博*,15 种药食同源中 药提取物抗氧化及抗骨质疏松活性研究. 中国食品学报,2017 , 17 (6) :240-248 .(EI)
(13) 丁燕*,孙浩,徐飞飞,曲丹,王枫琦,萧伟,朱靖博*,基于雌激素靶标的药食同源 中药抗骨质疏松活性网络药理学初探. 中国食品学报,2017, 17(12): 182-192. (EI)
(14) Xu Fei Fei, Ding Yan*, Guo Ying Ying, Liu Bao Yue, Kou Zi Nong, Xiao Wei, Zhu Jing Bo*, Anti-osteoporosis effect of Epimedium via an estrogen-like mechanism based on a system-level approach. Journal of Ethnopharmacology, 2016, 177: 148-160.(SCI, 2.998)
(15) Ding Yan, Qu Dan, Zhang Kai-Mei, Cang Xiao-Xin, Kou Zi-Nong, Xiao Wei, Zhu Jing-Bo Phytochemical and biological investigations of Amaryllidaceae alkaloids: a review, Journal of Asian Natural Products Research, 2016 , 19 (1) :53-100(SCI, 1.009)
(16) Guo Ying Ying, Ding Yan*, Xu Fei Fei, Liu Bao Yue, Kou Zi Nong, Xiao Wei, Zhu Jing Bo*, Systems pharmacology-based drug discovery for marine resources: An example using sea cucumber (Holothurians). Journal of Ethnopharmacology, 2015, 165: 61-72.(SCI, 2.998)
(17) Ding Yan, Kim Jeong Ah, Yang Seo Young, Kim Won-Ki, Lee Sang Hyun, Jang Hae Dong, Kim Young Ho*, Antioxidative Sesquiterpenes from Artemisia iwayomogi. Bulletin of the Korean Chemical Society, 2011, 32(9): 3493-3496. (SCI, 1.257)
(18) Ding Yan, Wu En Qi, Liang Chun, Chen Jian bo, Kang Jong Seong, Park Kyung Lae, Bae KiHwan, Kim Young Ho*, Quality evaluation and comparative study of Cinnamomi Ramulus and Cinnamomi Cortex in different countries based on HPLC fingerprintchromatogram and pattern analysis. Food Chemistry, 2011, 127, 755-760. (SCI, 3.146)
(19) Ding Yan, Liang Chun, Kim Jun Ho, Lee Young-Mi, Hyun Jae-Hee, Kang Hee-Kyoung, Kim Jeong-Ah, Min Byung Sun, Kim Young Ho*, Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters, 2010, 20(5): 1528-1531. (SCI, 2.531)
(20) Ding Yan, Liang Chun, Nguyen Huu Tung, Choi Eun Mi, Kim Jeong-Ah, Kim Young Ho*, Chemical constituents from Acer mandshuricum and their effects on the function of osteoblastic MC3T3-E1 cells. Bulletin of the Korean Chemical Society, 2010, 31(4): 929-933. (SCI, 1.257)
(21) Ding Yan, Liang Chun, Yang Seo Young, Chan Jeong, Choi Eun Mi, Kim Jeong-Ah, Kim Young Ho*, Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells. Biological & Pharmaceutical Bulletin, 2010, 33(8): 1448-1453. (SCI, 1.765)
(22) Ding Yan, Liang Chun, Yang Seo Young, Kim Jun Ho, Lee Young Mi, Kim Young Ho*, Iwayoside A, a new Diterpene Glycoside from Artemisia iwayomogi Kitamura that enhances IL-2 Secretion. Bulletin of the Korean Chemical Society, 2010, 31(8): 2422-2423. (SCI, 1.257)
(23) Ding Yan, Nguyen Huu Tung, Choi Eun Mi, Bae Kihwan, Kim Young Ho, Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 Cells. Planta medica, 2009, 75(2), 158-62. (SCI, 1.960)
(24) Ding Yan, Nguyen Huu Tung, Kim Sung In, Kim Ha Won, Kim Young Ho*, The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris. Bioorganic & Medicinal Chemistry Letters, 2009, 19(13): 3607-3610. (SCI, 2.531)
(25) Ding Yan, Bao Hai Ying, Bau Tolgor, Li Yu, Kim Young Ho*, Antitumor Components from Naematoloma fasciculare. Journal of Microbiology and Biotechnology, 2009, 19(10): 1135-1138. (SCI, 2.32)
(26) Ding Yan, Liang Chun, Choi Eun Mi, Ra Jeong Chan, Kim Young Ho*, Chemical Constituents from Artemisia iwayomogi Increase the Function of Osteoblastic MC3T3-E1Cells. Natural Product Sciences 2009, 15(4): 192-197.
(27) Ding Yan, Wu En Qi, Chen Jianbo, Nguyen Huu Tung, Do Thi Ha, Park Kyung Lae, Bae KiHwan, Kim Young Ho, Kang Jong Seong*, Quality evaluation of Moutan Cortex Radicis using multiple component analysis by High Performance Liquid Chromatography. Bulletin of the Korean Chemical Society, 2009, 30(10): 2240-2244. (SCI, 1.257)
(28) Ding Yan, BAO Hai-Ying, BAU Tolgor, LI Yu. Anti-tumor effect of Naematoloma fasciculare polysaccharide. 菌物学报, 2006, 25 (4):611-615.
(29) 丁 燕, 图力古尔, 包海鹰. 沿丝伞属真菌化学成分与药理学研究概况. 菌物学报, 2004, 23 (4):605-611.
(30) 包海鹰, 丁 燕, 李登科, 李玉. 胶陀螺发酵液的研究. 菌物研究, 2003,1(1):40-43.
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